Journal article
John Virostko, A. Sorace, Chengyue Wu, David A. Ekrut, A. M. Jarrett, Raghave M. Upadhyaya, Sarah Avery, D. Patt, B. Goodgame, T. Yankeelov
Tomography, 2019
Tomography, 2019
Semantic Scholar
DOI
PubMedCentral
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APA
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Virostko, J., Sorace, A., Wu, C., Ekrut, D. A., Jarrett, A. M., Upadhyaya, R. M., … Yankeelov, T. (2019). Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy. Tomography.
Chicago/Turabian
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Virostko, John, A. Sorace, Chengyue Wu, David A. Ekrut, A. M. Jarrett, Raghave M. Upadhyaya, Sarah Avery, D. Patt, B. Goodgame, and T. Yankeelov. “Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy.” Tomography (2019).
MLA
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Virostko, John, et al. “Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy.” Tomography, 2019.
BibTeX Click to copy
@article{john2019a,
title = {Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy},
year = {2019},
journal = {Tomography},
author = {Virostko, John and Sorace, A. and Wu, Chengyue and Ekrut, David A. and Jarrett, A. M. and Upadhyaya, Raghave M. and Avery, Sarah and Patt, D. and Goodgame, B. and Yankeelov, T.}
}
Abstract
Repeatability and reproducibility of magnetization transfer magnetic resonance imaging of the breast, and the ability of this technique to assess the response of locally advanced breast cancer to neoadjuvant therapy (NAT), are determined. Reproducibility scans at 3 different 3 T scanners, including 2 scanners in community imaging centers, found a 16.3% difference (n = 3) in magnetization transfer ratio (MTR) in healthy breast fibroglandular tissue. Repeatability scans (n = 10) found a difference of ∼8.1% in the MTR measurement of fibroglandular tissue between the 2 measurements. Thus, MTR is repeatable and reproducible in the breast and can be integrated into community imaging clinics. Serial magnetization transfer magnetic resonance imaging performed at longitudinal time points during NAT indicated no significant change in average tumoral MTR during treatment. However, histogram analysis indicated an increase in the dispersion of MTR values of the tumor during NAT, as quantified by higher standard deviation (P = .005), higher full width at half maximum (P = .02), and lower kurtosis (P = .02). Patients' stratification into those with pathological complete response (pCR; n = 6) at the conclusion of NAT and those with residual disease (n = 9) showed wider distribution of tumor MTR values in patients who achieved pCR after 2–4 cycles of NAT, as quantified by higher standard deviation (P = .02), higher full width at half maximum (P = .03), and lower kurtosis (P = .03). Thus, MTR can be used as an imaging metric to assess response to breast NAT.
